CXCR1 Antikörper (N-Term)

Produktnummer ABIN3042912

Produktdetails anti-CXCR1 Antikörper

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Bindungsspezifität: AA 24-38, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.

Sequenz: DEDYSPCMLE TETLN

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.
Gene Name: chemokine(C-X-C motif) receptor 1
Protein Name: C-X-C chemokine receptor type 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1(24-38aa DEDYSPCMLETETLN).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu CXCR1

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Andere Bezeichnung: CXCR1 (CXCR1 Produkte)

Synonyme: C-C antikoerper, C-C-CKR-1 antikoerper, CD128 antikoerper, CD181 antikoerper, CDw128a antikoerper, CKR-1 antikoerper, CMKAR1 antikoerper, IL8R1 antikoerper, IL8RA antikoerper, IL8RBA antikoerper, Il8ra antikoerper, CXCR-1 antikoerper, IL-8RA antikoerper, CXCR2 antikoerper, IL8RB antikoerper, cxcr1 antikoerper, cxcr2 antikoerper, C-X-C motif chemokine receptor 1 antikoerper, chemokine (C-X-C motif) receptor 1 antikoerper, C-X-C chemokine receptor type 1 antikoerper, C-X-C motif chemokine receptor 1 S homeolog antikoerper, CXCR1 antikoerper, Cxcr1 antikoerper, LOC100461947 antikoerper, cxcr1.S antikoerper

Hintergrund: CXCR1(Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al.(1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA(GRO) with a low affinity.

Synonyms: C C antibody|C C CKR 1 antibody|C-X-C chemokine receptor type 1 antibody|CCCKR1 antibody|CD 181 antibody|CD128 antibody|CD181 antibody|CD181 antigen antibody|CDw128a antibody|Chemokine(C X C motif) receptor 1 antibody|Chemokine(C X C) receptor 1 antibody|Chemokine receptor 1 antibody|CKR 1 antibody|CMKAR1 antibody|CXC-R1 antibody|CXCR 1 antibody|CXCR-1 antibody|CXCR1 antibody|CXCR1_HUMAN antibody|High affinity interleukin 8 receptor A antibody|High affinity interleukin-8 receptor A antibody|IL 8 receptor type 1 antibody|IL 8R A antibody|IL-8 receptor type 1 antibody|IL-8R A antibody|IL8 receptor antibody|IL8 receptor type 1 antibody|IL8R1 antibody|IL8RA antibody|IL8RBA antibody|Interleukin 8 receptor alpha antibody|Interleukin 8 receptor type 1 antibody|Interleukin 8 receptor type A antibody

UniProt: P25024

Pathways: cAMP Metabolic Process