CDK5 Antikörper (C-Term)

Produktnummer ABIN3042679

Produktdetails anti-CDK5 Antikörper

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Bindungsspezifität: AA 273-292, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Cyclin-dependent-like kinase 5(CDK5) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: QRISAEEALQ HPYFSDFCPP

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Cyclin-dependent-like kinase 5(CDK5) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: cyclin-dependent kinase 5
Protein Name: Cyclin-dependent-like kinase 5

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cdk5(273-292aa QRISAEEALQHPYFSDFCPP), identical to the related rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-CDK5 Antikörper (ABIN3042679)

Li, Zhang, Zhu, Zhang, Lin, Xu, Yang, Hao, Zhang: "A new treatment for cognitive disorders related to in utero exposure to alcohol." in: Neural regeneration research, Vol. 8, Issue 18, pp. 1702-13, (2014) (PubMed).

Details zu CDK5

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Andere Bezeichnung: CDK5 (CDK5 Produkte)

Synonyme: PSSALRE antikoerper, AW048668 antikoerper, Crk6 antikoerper, CDK5 antikoerper, CG8203 antikoerper, DmCdk5 antikoerper, Dmel\\CG8203 antikoerper, cdk5 antikoerper, zgc:101604 antikoerper, cyclin dependent kinase 5 antikoerper, cyclin-dependent kinase 5 antikoerper, Cyclin-dependent kinase 5 antikoerper, cyclin-dependent kinase 5 L homeolog antikoerper, Cyclin-dependent-like kinase 5 antikoerper, CDK5 antikoerper, Cdk5 antikoerper, cdk5 antikoerper, cdk5.L antikoerper, cdk-5 antikoerper

Hintergrund: CDK5, Cyclin-Dependent Kinase5, is also know as PSSALRE. The p34(CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35(CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.

Synonyms: Cdk 5 antibody|Cdk5 antibody|CDK5_HUMAN antibody|Cell division protein kinase 5 antibody|Crk6 antibody|Cyclin dependent kinase 5 antibody|Cyclin-dependent kinase 5 antibody|Protein kinase CDK5 splicing antibody|PSSALRE antibody|Serine threonine protein kinase PSSALRE antibody|Serine/threonine-protein kinase PSSALRE antibody|Tau protein kinaseII catalytic subunit antibody|TPKII catalytic subunit antibody

UniProt: Q00535

Pathways: Zellzyklus, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis