CDK5 Antikörper (AA 1-226)

Produktnummer ABIN6719393

Der Kaninchen Polyklonal anti-CDK5 Antikörper wird verwendet zum Nachweis von CDK5 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für CDK5 Antikörper (AA 1-226) (ABIN6719393)

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CDK5 Antikörper

Bindungsspezifität: AA 1-226

Verwendungszweck: Anti-CDK5 Antibody

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-CDK5 Antibody. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CDK5 recombinant protein (Position: M1-Q226).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL ELISA, 0.1-0.5 μg/mL

Kommentare:

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CDK5

Target: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Andere Bezeichnung: CDK5

Hintergrund:

Background: CDK5, Cyclin-Dependent Kinase5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle.The PSSALRE expression is in all human tissues and cell lines tested.The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.

Gene Full Name: cyclin dependent kinase 5

Molekulargewicht: 33 kDa

Gen-ID: 1020

UniProt: Q00535

Pathways: Zellzyklus, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis