IL-8 Antikörper (C-Term)

Produktnummer ABIN3042619

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL-8 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 39+ Publikationen erwähnt.

Kurzübersicht für IL-8 Antikörper (C-Term) (ABIN3042619)

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-IL-8 Antikörper

Bindungsspezifität: AA 77-95, C-Term

Verwendungszweck: Anti-IL8/CXCL8 Antibody Picoband®

Sequenz: CLDPKENWVQ RVVEKFLKR

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-IL8/CXCL8 Antibody (ABIN3042619). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IL8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. Wolff B, Burns AR, Middleton J, Rot A (November 1998). "Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies". 2. Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (November 1998). "Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells". 3. Modi WS, Dean M, Seuanez HN, Mukaida N, Matsushima K, O'Brien SJ (January 1990). "Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily". 4. "Entrez Gene: IL8 interleukin 8". 5. Köhidai L, Csaba G (July 1998). "Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-alpha) in the unicellular Tetrahymena pyriformis". 6. O'Donovan, N., Galvin, M., Morgan, J. G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL-8 Antikörper (ABIN3042619)

Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

Yu, Lu, Li, Xiao, Xing, Li, Wu: "Role of S100A1 in hypoxia-induced inflammatory response in cardiomyocytes via TLR4/ROS/NF-?B pathway." in: The Journal of pharmacy and pharmacology, Vol. 67, Issue 9, pp. 1240-50, (2015) (PubMed).

Zhang, Xia, Han, Jiang, Rong, Song, Wang: "Cathelicidin-BF, a Novel Antimicrobial Peptide from Bungarus fasciatus, Attenuates Disease in a Dextran Sulfate Sodium Model of Colitis." in: Molecular pharmaceutics, Vol. 12, Issue 5, pp. 1648-61, (2015) (PubMed).

Xiao, Gang, Wang, Wang, Zhao, Xu, Liu: "Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy." in: Biochemical and biophysical research communications, Vol. 457, Issue 2, pp. 221-6, (2015) (PubMed).

Ren, Li, Hu, Wang, Hu: "Melatonin regulates the rhythmic migration of neutrophils in live zebrafish." in: Journal of pineal research, Vol. 58, Issue 4, pp. 452-60, (2015) (PubMed).

Capsoni, Ongari, Lonati, Accetta, Gatti, Catania: "?-Melanocyte-stimulating-hormone (?-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines." in: BMC musculoskeletal disorders, Vol. 16, pp. 154, (2015) (PubMed).

Dong, Zhong, Lu, Li, Jiang, Mao: "Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-?B Pathway in HBE16 Airway Epithelial Cells." in: Inflammation, Vol. 38, Issue 4, pp. 1493-501, (2015) (PubMed).

Wang, Zhuo, Hu, Shen, Zhang, Chu: "CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis." in: Biochemical and biophysical research communications, Vol. 458, Issue 2, pp. 268-73, (2015) (PubMed).

Pei, Li, Zhan, Yu, Wei, Guan, Aydin, Elson, Zhou, He, Zhang: "Enhanced IMP3 Expression Activates NF-?B Pathway and Promotes Renal Cell Carcinoma Progression." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124338, (2015) (PubMed).

Yu, Liu, Chen, Zeng: "Anti-inflammatory effect of Qingwen Baidu Decoction (?????) in sepsis rats." in: Chinese journal of integrative medicine, Vol. 20, Issue 12, pp. 934-43, (2014) (PubMed).

Li, Qian, Ju, Wang: "Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus." in: Oncology letters, Vol. 9, Issue 1, pp. 365-370, (2014) (PubMed).

Huang, Du, Fan, Lv, Qian, Zhang, Han, Chen, Wu, Jin: "The effect of proinflammatory cytokines on IL-17RA expression in NSCLC." in: Medical oncology (Northwood, London, England), Vol. 31, Issue 9, pp. 144, (2014) (PubMed).

Liu, Zhang, Xiao, Dai, Sun, Chen, Chen: "Three-dimensional collagen scaffold enhances the human adenoid cystic carcinoma cancer stem cell and epithelial-mesenchymal transition properties." in: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 102, Issue 4, pp. 772-80, (2014) (PubMed).

Hu, Yang, Zhang, Liu, Zhang, Lin, Huang, Wang, Zhang, Zhong, Shu: "TRIM38 inhibits TNF?- and IL-1?-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 4, pp. 1509-14, (2014) (PubMed).

Zhang, Feng, Liu, Zhang, Liang, Tang: "Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1?, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells." in: PLoS ONE, Vol. 9, Issue 7, pp. e103440, (2014) (PubMed).

Bao, Zhang, Lou, Xiao, Cheng, Zhou: "Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS." in: Canadian journal of physiology and pharmacology, Vol. 92, Issue 4, pp. 299-306, (2014) (PubMed).

Li, Yang, Yao, Li, Tian, Li, Jiang, Wang, Li, Guo: "Effects and mechanism of bufei yishen formula in a rat chronic obstructive pulmonary disease model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 381976, (2014) (PubMed).

Zhai, Han, Shan, Qu, Guo, Zhou: "Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells." in: Molecular medicine reports, Vol. 10, Issue 6, pp. 3052-8, (2014) (PubMed).

Zhang, Zhang, Deng, Li, Xing, Shi, Du: "Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus." in: Neural regeneration research, Vol. 9, Issue 15, pp. 1446-52, (2014) (PubMed).

Liu, Shan, Dong, Liu, Ma, Liu: "Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury." in: World journal of gastroenterology, Vol. 19, Issue 4, pp. 492-502, (2013) (PubMed).

Details zu IL-8

Target: IL-8 (IL8) (Interleukin 8 (IL8))

Andere Bezeichnung: IL8

Hintergrund:

Synonyms: Interleukin-8,IL-8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,GCP-1,Monocyte-derived neutrophil chemotactic factor,MDNCF,Monocyte-derived neutrophil-activating peptide,MONAP,Neutrophil-activating protein 1,NAP-1,Protein 3-10C,T-cell chemotactic factor,MDNCF-a,GCP/IL-8 protein IV,IL8/NAP1 form I,Interleukin-8, (Ala-IL-8)77,GCP/IL-8 protein II,IL-8 (1-77),IL8/NAP1 form II,MDNCF-b,IL-8 (5-77),IL-8 (6-77), (Ser-IL-8)72,GCP/IL-8 protein I,IL8/NAP1 form III,Lymphocyte-derived neutrophil-activating factor,LYNAP,MDNCF-c,Neutrophil-activating factor,NAF,IL-8 (7-77),GCP/IL-8 protein V,IL8/NAP1 form IV,IL-8 (8-77),GCP/IL-8 protein VI,IL8/NAP1 form V,IL-8 (9-77),GCP/IL-8 protein III,IL8/NAP1 form VI,CXCL8,IL8,

Tissue Specificity: Widely expressed, lower levels in brain and lung.

Background: Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8 (IL8) is a member of the CXC chemokine family (Hull et al., 2001). IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment.

Sequence Similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Molekulargewicht: 60 kDa

UniProt: P10145

Pathways: TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagie