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HCN1 Antikörper (AA 618-890)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HCN1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN3042439

Kurzübersicht für HCN1 Antikörper (AA 618-890) (ABIN3042439)

Target

Alle HCN1 Antikörper anzeigen
HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Reaktivität

  • 33
  • 27
  • 13
  • 1
Human, Ratte, Maus

Wirt

  • 31
  • 22
  • 2
  • 1
Kaninchen

Klonalität

  • 34
  • 22
Polyklonal

Konjugat

  • 28
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HCN1 Antikörper ist unkonjugiert

Applikation

  • 41
  • 38
  • 17
  • 16
  • 10
  • 8
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 18
    • 9
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 618-890

    Verwendungszweck

    Anti-HCN1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-HCN1 Antibody Picoband® (ABIN3042439). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815-20. 2. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717-29. 3. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455-62. 4. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1"

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

    Andere Bezeichnung

    HCN1

    Hintergrund

    Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Brain cyclic nucleotide-gated channel 1,BCNG-1,HCN1,BCNG1,

    Tissue Specificity: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. .

    Background: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.

    Sequence Similarities: Belongs to the potassium channel HCN family.

    Molekulargewicht

    120 kDa

    Gen-ID

    348980

    UniProt

    O60741

    Pathways

    Asymmetric Protein Localization
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