Caspase 2 Antikörper (N-Term)

Produktnummer ABIN303201

Der Kaninchen Polyklonal anti-Caspase 2 Antikörper (ABIN303201) detektiert spezifisch Caspase 2 in WB, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Caspase 2 Antikörper (N-Term) (ABIN303201)

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Caspase 2 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 16 Amino Acid peptide from the amino-terminus of human Caspase-2.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (10 μg/mL). Immunocytochemistry. Western Blot (1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Details zu Caspase 2

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Andere Bezeichnung: Caspase-2

Hintergrund: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms, overexpression on the long form results in apoptosis while that of the short form suppresses cell death.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2

Gen-ID: 835

NCBI Accession: NP_001215

UniProt: P42575

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Neurotrophin Signalübertragung