KIT Ligand Antikörper (AA 26-44)

Produktnummer ABIN3031560

Dieses Anti-KIT Ligand-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KIT Ligand in WB und IHC (p). Geeignet für Human.

Kurzübersicht für KIT Ligand Antikörper (AA 26-44) (ABIN3031560)

Target: KIT Ligand (KITLG)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIT Ligand Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-KIT Ligand Antikörper

Bindungsspezifität: AA 26-44

Aufreinigung: Antigen affinity

Immunogen: Amino acids 26-44 (DEGICRNRVTNNVKDVTKLV-human) were used as the immunogen for this SCF antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the SCF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SCF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu KIT Ligand

Target: KIT Ligand (KITLG)

Andere Bezeichnung: SCF

Hintergrund: Stem Cell Factor (also called kit-ligand, KL1, and Steel factor) is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. It is localized to the long arm of human chromosome 12, between 12q14.3 and 12qter. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. It has been shown to increase the survival of HSCs in vitro and contributes to the self renewal and maintenance of HSCs in-vivo. HSCs at all stages of development express the same levels of the receptor for SCF (c-Kit). The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF.

UniProt: P21583

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung