Insulin Receptor Antikörper (AA 1353-1372)

Produktnummer ABIN3031334

Der Kaninchen Polyklonal Anti-Insulin Receptor-Antikörper wurde für WB validiert. Er ist geeignet, Insulin Receptor in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Insulin Receptor Antikörper (AA 1353-1372) (ABIN3031334)

Target: Insulin Receptor (INSR)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Insulin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Insulin Receptor Antikörper

Bindungsspezifität: AA 1353-1372

Aufreinigung: Antigen affinity

Immunogen: Amino acids 1353-1372 (RSYEEHIPYTHMNGGKKNGR) were used as the immunogen for this Insulin Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Insulin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Insulin Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Insulin Receptor

Target: Insulin Receptor (INSR)

Andere Bezeichnung: Insulin Receptor

Hintergrund: INSR (Insulin Receptor) is a tetramer of two alpha and two beta subunits that are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. It belongs to the large class of tyrosine kinase receptors. The insulin receptor mediates their activity by causing the addition of a phosphate group to particular tyrosines on certain proteins within a cell. The INSR gene spans more than 120 kb and has 22 exons. Functional studies of the INSR SNPs show no effect on mRNA levels or splicing in peripheral blood leukocytes or on binding of insuln to mononuclear cells.

UniProt: P06213

Pathways: NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity