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Huntingtin Antikörper (C-Term)

Dieses Anti-Huntingtin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Huntingtin in WB. Geeignet für Human, Ratte und Maus.
Produktnummer ABIN3031257

Kurzübersicht für Huntingtin Antikörper (C-Term) (ABIN3031257)

Target

Alle Huntingtin (HTT) Antikörper anzeigen
Huntingtin (HTT)

Reaktivität

  • 63
  • 48
  • 41
  • 6
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 60
  • 24
  • 2
Kaninchen

Klonalität

  • 51
  • 34
Polyklonal

Konjugat

  • 65
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Huntingtin Antikörper ist unkonjugiert

Applikation

  • 48
  • 38
  • 36
  • 20
  • 14
  • 14
  • 13
  • 12
  • 9
  • 8
  • 4
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Aufreinigung

    Antigen affinity

    Immunogen

    An amino acid sequence from the C-terminus of human HTT (ELDRRAFQSVLEVVAA) was used as the immunogen for this Huntingtin antibody.

    Isotyp

    IgG
  • Applikationshinweise

    The stated application concentrations are suggested starting amounts. Titration of the Huntingtin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the Huntingtin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    Huntingtin (HTT)

    Andere Bezeichnung

    Huntingtin

    Hintergrund

    The Huntingtin gene, also called HTT or HD (Huntington disease), is the IT15 (interesting transcript 15) gene which codes for a protein called the Huntingtin. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. HTT is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. Additionally, wildtype Huntingtin may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

    UniProt

    P42858

    Pathways

    PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
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