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Gelsolin Antikörper (AA 763-775)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Gelsolin in WB, ICC und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN3031036

Kurzübersicht für Gelsolin Antikörper (AA 763-775) (ABIN3031036)

Target

Alle Gelsolin (GSN) Antikörper anzeigen
Gelsolin (GSN)

Reaktivität

  • 126
  • 39
  • 33
  • 12
  • 7
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 102
  • 43
  • 2
Kaninchen

Klonalität

  • 94
  • 53
Polyklonal

Konjugat

  • 95
  • 10
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Gelsolin Antikörper ist unkonjugiert

Applikation

  • 115
  • 70
  • 53
  • 53
  • 26
  • 23
  • 16
  • 16
  • 14
  • 13
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 16
    • 8
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 763-775

    Aufreinigung

    Antigen affinity

    Immunogen

    Amino acids 763-775 (WDDDYWSVDPLDR-human) were used as the immunogen for this Gelsolin antibody (100% rat homology).

    Isotyp

    IgG
  • Applikationshinweise

    The stated application concentrations are suggested starting amounts. Titration of the Gelsolin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the Gelsolin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    Gelsolin (GSN)

    Andere Bezeichnung

    Gelsolin

    Hintergrund

    Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. It is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor, it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. It may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of Gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.

    UniProt

    P06396

    Pathways

    Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie
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