Aurora A Antikörper

Produktnummer ABIN303027

Der Ziege Polyklonal anti-Aurora A Antikörper (ABIN303027) detektiert spezifisch Aurora A in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Aurora A Antikörper (ABIN303027)

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Aurora A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Aurora A Antikörper

Spezifität: This antibody reacts to the C Terminus of Aurora kinase A / STK15: peptide sequence (QNKESASKQS).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sectons: 10 μg/mL. Western Blot: 0,5 - 2 μg/mL. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline containing 0.5 % BSA and 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu Aurora A

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Andere Bezeichnung: Aurora Kinase A

Hintergrund: ARK1, an Aurora/IPL1-like protein kinase, functions in centrosome separation, duplication, and maturation and in bipolar spindle assembly and stability. The protein has been shown to localize to centrosomes in S phase as soon as centrioles have been duplicated, and to be degraded in early G1. ARK1 phosphorylation is induced by okadaic acid treatment in vivo. Activated ARK1 has been shown to phosphorylate the spindle apparatus-associated protein, TPX2, and it is believed to be targeted to the spindle apparatus by this protein. At least three alternative splice forms have been reported, however, the alternative splice sites are located in the 5'-untranslated region and appear to have no effect on protein translation. ARK1 has been identified as an oncogene that is overexpressed in several types of solid tumors and tumor cell lines, including those from breast and colon. Additionally, overexpression of ARK1 has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy, and genomic instability.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6

Gen-ID: 6790

NCBI Accession: NP_003591

UniProt: O14965

Pathways: Zellzyklus, Asymmetric Protein Localization