Insulin Receptor Antikörper (Chain beta, Internal Region)

Produktnummer ABIN302612

Der Kaninchen Polyklonal Anti-Insulin Receptor-Antikörper wurde für IHC (p) validiert. Er ist geeignet, Insulin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Insulin Receptor Antikörper (Chain beta, Internal Region) (ABIN302612)

Target: Insulin Receptor (INSR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Insulin Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Insulin Receptor Antikörper

Bindungsspezifität: Chain beta, Internal Region

Spezifität: This antibody detects Insulin Receptor (INSR) at internal domain.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: INSR antibody was raised against synthetic peptide from internal domain of human INSR / Insulin Receptor.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin section (10 μg/mL)Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undlited at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Details zu Insulin Receptor

Target: Insulin Receptor (INSR)

Andere Bezeichnung: CD220 / INSR

Hintergrund: INSR is an insulin receptor type protein kinase. Binding of insulin to INSR stimulates glucose uptake. Two insulin receptor mRNA transcripts resulting from alternative splicing of exon 11 in the receptor gene are expressed in a highly regulated tissue-specific fashion. Mutations in the INSR gene contribute to diseases, including of various forms of insulin resistance, insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus (NIDDM), Rabson-Mendenhall syndrome and Leprechaunism (Donohue Syndrome).Synonyms: Insulin Receptor

Gen-ID: 3643

NCBI Accession: NP_000199

UniProt: P06213

Pathways: NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity