CD46 Antikörper

Produktnummer ABIN3025892

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD46 in FACS und IF. Er zeigt eine Reaktivität gegenüber Human und Pavian.

Kurzübersicht für CD46 Antikörper (ABIN3025892)

Target: CD46

Reaktivität: Human, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: 169-1-E4-3

Produktdetails anti-CD46 Antikörper

Keine Kreuzreaktivität: Pferd

Aufreinigung: Protein G affinity chromatography

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CD46 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the CD46 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46

Hintergrund: Recognizes a protein of 52  kDa-58  kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Pathways: Regulation of Actin Filament Polymerization