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ACTH Antikörper (AA 1-24)

ACTH Reaktivität: Human, Ratte, Maus IF, FACS, ELISA, IHC (p) Wirt: Maus Monoclonal 2F6 unconjugated
Produktnummer ABIN3025415
  • Target Alle ACTH Antikörper anzeigen
    ACTH (Adrenocorticotropic hormone (ACTH))
    Bindungsspezifität
    • 36
    • 33
    • 19
    • 15
    • 14
    • 8
    • 2
    • 2
    AA 1-24
    Reaktivität
    • 118
    • 83
    • 49
    • 5
    • 3
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 81
    • 56
    Maus
    Klonalität
    • 81
    • 56
    Monoklonal
    Konjugat
    • 51
    • 13
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser ACTH Antikörper ist unkonjugiert
    Applikation
    • 70
    • 69
    • 68
    • 67
    • 35
    • 34
    • 25
    • 25
    • 23
    • 18
    • 11
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Protein G affinity chromatography
    Immunogen
    A synthetic peptide corresponding to aa 1-24 of human ACTH was used as the immunogen for this antibody.
    Klon
    2F6
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product ACTH Primärantikörper
  • Applikationshinweise
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

    1. No special pretreatment is required for staining of formalin-fixed tissues.\. ELISA: order BSA-free format for coating,FACS: 0.5-1 μg/million cells,IF: 0.5-1 μg/mL,IHC (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.2 mg/mL
    Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the ACTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    ACTH (Adrenocorticotropic hormone (ACTH))
    Andere Bezeichnung
    ACTH / Synacthen (ACTH Produkte)
    Synonyme
    ACTH antikoerper, BE antikoerper, Beta-LPH antikoerper, Clip antikoerper, Gamma-LPH antikoerper, Npp antikoerper, Pomc-1 antikoerper, Pomc1 antikoerper, alpha-MSH antikoerper, alphaMSH antikoerper, beta-MSH antikoerper, gamma-MSH antikoerper, CLIP antikoerper, LPH antikoerper, MSH antikoerper, NPP antikoerper, POC antikoerper, pro-opiomelanocortin-alpha antikoerper, proopiomelanocortin antikoerper, Pomc antikoerper, POMC antikoerper
    Substanzklasse
    Hormone
    Hintergrund
    POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH (also called Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This antibody is specific to Synacthen (aa 1-24 of ACTH) and does not react with CLIP (aa 17-39 of ACTH). ACTH is produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. ACTH antibody is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
    Gen-ID
    5443
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity
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