PAX6 Antikörper

Produktnummer ABIN3025378

Der Maus Monoklonal anti-PAX6 Antikörper (Klon PAX6-498) (ABIN3025378) detektiert spezifisch PAX6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PAX6 Antikörper (ABIN3025378)

Target: PAX6 (Paired Box 6 (PAX6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAX6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Klon: PAX6-498

Produktdetails anti-PAX6 Antikörper

Verwendungszweck: PAX6 Antibody (azide and preservative free)

Aufreinigung: Protein G purified antibody

Immunogen: Recombinant human PAX6 protein was used as the immunogen for this antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the PAX6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Andere Bezeichnung: PAX6

Hintergrund: PAX genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the PAX6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The PAX6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human PAX6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis