Cyclin B1 Antikörper (C-Term)

Produktnummer ABIN3022807

Der Kaninchen Polyklonal Anti-Cyclin B1-Antikörper wurde für WB und IF validiert. Er ist geeignet, Cyclin B1 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für Cyclin B1 Antikörper (C-Term) (ABIN3022807)

Target: Cyclin B1 (CCNB1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Cyclin B1 Antikörper

Bindungsspezifität: C-Term

Sequenz: TMLDYDMVHF PPSQIAAGAF CLALKILDNG EWTPTLQHYL SYTEESLLPV MQHLAKNVVM VNQGLTKHMT VKNKYATSKH AKISTLPQLN SALVQDLAKA VAKV

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 330 to the C-terminus of human Cyclin B1 (NP_114172.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Cyclin B1 Antikörper (ABIN3022807)

Dong, Zheng, Wang, Tang, Yan, Zhou, Huang: "A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer." in: European journal of pharmacology, Vol. 828, pp. 67-79, (2018) (PubMed).

Deng, Li, Zhao, Yuan, Li: "Antitumor activity of the microtubule inhibitor MBRI-001 against human hepatocellular carcinoma as monotherapy or in combination with sorafenib." in: Cancer chemotherapy and pharmacology, Vol. 81, Issue 5, pp. 853-862, (2018) (PubMed).

Tsai, Yu, Lin, Cheng, Chen, Pang: "Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 149, Issue 2, pp. 326-34, (2016) (PubMed).

Cheng, Yang, Fang, Ma, Gong, Wang, Li, Xu: "Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation." in: Nature communications, Vol. 6, pp. 7023, (2015) (PubMed).

Yu, Pang, Wu, Lin, Tseng, Tsai: "Platelet-rich plasma increases proliferation of tendon cells by modulating Stat3 and p27 to up-regulate expression of cyclins and cyclin-dependent kinases." in: Cell proliferation, Vol. 48, Issue 4, pp. 413-20, (2015) (PubMed).

Details zu Cyclin B1

Target: Cyclin B1 (CCNB1)

Andere Bezeichnung: CCNB1

Hintergrund: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.,CCNB,CCNB1,Cyclin B1,cyclin B1,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cyclins,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,CCNB1

Molekulargewicht: 44 kDa/48 kDa

Gen-ID: 891

UniProt: P14635

Pathways: Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase