CD44 Antikörper (AA 35-300)

Produktnummer ABIN3021913

Der Kaninchen Polyklonal Anti-CD44-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CD44 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für CD44 Antikörper (AA 35-300) (ABIN3021913)

Target: CD44

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CD44 Antikörper

Bindungsspezifität: AA 35-300

Sequenz: HVEKNGRYSI SRTEAADLCK AFNSTLPTMA QMEKALSIGF ETCRYGFIEG HVVIPRIHPN SICAANNTGV YILTSNTSQY DTYCFNASAP PEEDCTSVTD LPNAFDGPIT ITIVNRDGTR YVQKGEYRTN PEDIYPSNPT DDDVSSGSSS ERSSTSGGYI FYTFSTVHPI PDEDSPWITD STDRIPATST SSNTISAGWE PNEENEDERD RHLSFSGSGI DDDEDFISST ISTTPRAFDH TKQNQDWTQW NPSHSNPEVL LQTTTR

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human CD44 (NP_001001389.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-CD44 Antikörper (ABIN3021913)

Ji, Yang, Tang, Yang, Tian, Yao, Zhu, Zhang, Ji, Zheng: "Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation." in: Nature communications, Vol. 8, pp. 15308, (2018) (PubMed).

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,CD44,CD44,Cancer,Tumor immunology,Tumor biomarkers,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,CD44

Molekulargewicht: 3 kDa/15 kDa/32-53 kDa/73-81 kDa

Gen-ID: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling