Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Hexokinase 2 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid freeze / thaw cycles
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Guo, Yao, Zhan, Hu, Yue, Cheng, Liu, Ye, Qing, Zhang, Liu: "N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation." in: Toxicology and applied pharmacology, Vol. 280, Issue 3, pp. 475-83, (2014) (PubMed).
Target
Hexokinase 2 (HK2)
Andere Bezeichnung
HK2
Hintergrund
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.,HK2,HKII,HXK2,hexokinase-2,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,Warburg Effect,Cardiovascular,Heart,Cardiac metabolism,HK2