INPP5D Antikörper (N-Term)

Produktnummer ABIN302081

Der Maus Monoklonal Anti-INPP5D-Antikörper wurde für WB, ICC und ICFC validiert. Er ist geeignet, INPP5D in Proben von Human zu detektieren.

Kurzübersicht für INPP5D Antikörper (N-Term) (ABIN302081)

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser INPP5D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Intracellular Flow Cytometry (ICFC)

Klon: SHIP-01

Produktdetails anti-INPP5D Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Anti-SHIP1 Purified

Spezifität: The antibody SHIP-01 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells (intracellular antigen). Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.

Kreuzreaktivität (Details): Human, Other not determined

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Peptide coresponding to a sequence within N-terminal domain of human SHIP-1.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Intracellular staining, recommended dilution: 2-5 μg/mL, positive control: human blood leukocytes.
Western blotting: Positive control: RAMOS human cell line, reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu INPP5D

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Andere Bezeichnung: SHIP1

Hintergrund: Inositol polyphosphate-5-phosphatase D,SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.,IPP5PD, IP5PD, INPP5D

Gen-ID: 3635

UniProt: Q92835

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling, Warburg Effekt