LIMK2 Antikörper (pThr505)

Produktnummer ABIN3020313

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LIMK2 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LIMK2 Antikörper (pThr505) (ABIN3020313)

Target: LIMK2 (LIM Domain Kinase 2 (LIMK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIMK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-LIMK2 Antikörper

Bindungsspezifität: pThr505

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Phosphorylated Antibodies

Immunogen: A phospho specific peptide corresponding to residues surrounding T505 of human LIMK2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LIMK2

Target: LIMK2 (LIM Domain Kinase 2 (LIMK2))

Andere Bezeichnung: LIMK2

Hintergrund: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.,LIMK2,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,TGF-b-Smad Signaling Pathway,Protein phosphorylation,LIMK2

Molekulargewicht: 69 kDa/72 kDa/77 kDa

Gen-ID: 3985

UniProt: P53671