EGFR Antikörper (pTyr1068)

Produktnummer ABIN3020070

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EGFR in WB und IP. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für EGFR Antikörper (pTyr1068) (ABIN3020070)

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-EGFR Antikörper

Bindungsspezifität: pTyr1068

Kreuzreaktivität: Human, Maus

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding Y1068 of human EGFR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000,IP,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-EGFR Antikörper (ABIN3020070)

Zhang, Han, Lu, Zhao, Chen, Meng, Cao, Cai, Hu: "USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma." in: Cancer letters, Vol. 433, pp. 186-198, (2018) (PubMed).

Details zu EGFR

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung: EGFR

Hintergrund: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.,EGFR,ERBB,ERBB1,HER1,NISBD2,PIG61,mENA,Cancer,Tumor biomarkers,Signal Transduction,G protein signaling,Kinase,Tyrosine kinases,Phospholipase Signaling Pathway,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,EGF,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Cardiovascular,Angiogenesis,Protein phosphorylation,EGFR

Molekulargewicht: 44 kDa/69 kDa/77 kDa/134 kDa

Gen-ID: 1956

UniProt: P00533

Pathways: NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine