c-MYC Antikörper (pThr58)

Produktnummer ABIN3019539

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch c-MYC in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für c-MYC Antikörper (pThr58) (ABIN3019539)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MYC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-c-MYC Antikörper

Bindungsspezifität: pThr58

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding T58 of human MYC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung: MYC

Hintergrund: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.,MRTL,MYCC,bHLHe39,c-Myc,MYC,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor biomarkers,Signal Transduction,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,G1/S Checkpoint,Hedgehog Signaling Pathway,Notch Signaling Pathway,Endocrine & Metabolism,Warburg Effect,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Stem Cells,Protein phosphorylation,MYC

Molekulargewicht: 48 kDa/50 kDa

Gen-ID: 4609

UniProt: P01106

Pathways: p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt