CXCR7 Antikörper

Produktnummer ABIN2857021

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CXCR7 in WB, FACS, ELISA, IF, IHC (p), IP, ICC und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 7+ Publikationen zitiert.

Kurzübersicht für CXCR7 Antikörper (ABIN2857021)

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Güteklasse: KO Validated

Produktdetails anti-CXCR7 Antikörper

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to CXCR7 (C-X-C chemokine receptor type 7)
CXCR7 antibody [C1C2], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CXCR7. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validatio: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.92 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-CXCR7 Antikörper (ABIN2857021)

Wei, Huang, Hsieh, Lin, Shyu, Chen, Hsieh: "Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling." in: Cell death & disease, Vol. 11, Issue 5, pp. 307, (2020) (PubMed).

Liu, Song, Setroikromo, Chen, Hu, Chen, van der Wekken, Melgert, Timens, van den Berg, Saber, Haisma: "CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor." in: Cancers, Vol. 11, Issue 4, (2019) (PubMed).

Xu, Tang, Wang, Liu, Fu, Luo: "CXCR7 promotes melanoma tumorigenesis via Src kinase signaling." in: Cell death & disease, Vol. 10, Issue 3, pp. 191, (2019) (PubMed).

Tam, Ko, Koon, Cheng, Lok, Lau, Leung, Fung, Chan, Lau: "Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139342, (2016) (PubMed).

Liu, Carson-Walter, Walter: "Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells." in: PLoS ONE, Vol. 9, Issue 8, pp. e103938, (2015) (PubMed).

Salazar, Muñoz, Kallifatidis, Singh, Jordà, Lokeshwar: "The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation." in: Molecular cancer, Vol. 13, pp. 198, (2014) (PubMed).

Singh, Lokeshwar: "The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth." in: Cancer research, Vol. 71, Issue 9, pp. 3268-77, (2011) (PubMed).

Details zu CXCR7

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Andere Bezeichnung: atypical chemokine receptor 3

Hintergrund: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.

Cellular Localization: Cell membrane

Molekulargewicht: 41 kDa

Gen-ID: 57007

UniProt: P25106

Pathways: Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling