H2AFZ Antikörper (N-Term)

Produktnummer ABIN2856590

Produktdetails anti-H2AFZ Antikörper

Target: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFZ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Whole Mount) (IHC (wm))

Kreuzreaktivität: Human, Zebrafisch (Danio rerio)

Produktmerkmale: Rabbit Polyclonal antibody to Histone H2A.Z (H2A histone family, member Z)
Histone H2A.Z antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Histone H2A.Z. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.52 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-H2AFZ Antikörper (ABIN2856590)

Piquet, Le Parc, Bai, Chevallier, Adam, Polo: "The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage." in: Molecular cell, Vol. 72, Issue 5, pp. 888-901.e7, (2018) (PubMed).

Details zu H2AFZ

Target: H2AFZ (H2A Histone Family, Member Z (H2AFZ))

Andere Bezeichnung: H2A histone family member Z (H2AFZ Produkte)

Synonyme: H2A.Z-1 antikoerper, H2A.z antikoerper, H2A/z antikoerper, H2AZ antikoerper, H2A.Z antikoerper, H2a.z-1 antikoerper, H2AFV antikoerper, H2Az antikoerper, XH2AZ antikoerper, h2a.zl1 antikoerper, h2a.zl2 antikoerper, H2A histone family member Z antikoerper, H2A histone family, member Z antikoerper, H2A histone family member Z L homeolog antikoerper, histone H2A.Z antikoerper, H2AFZ antikoerper, H2afz antikoerper, h2afz.L antikoerper

Hintergrund: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Cellular Localization: Nucleus

Molekulargewicht: 14 kDa

Gen-ID: 3015

UniProt: P0C0S5

Pathways: Telomere Maintenance