LOXL2 Antikörper

Produktnummer ABIN2856034

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LOXL2 in WB, IHC, ELISA, ICC, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für LOXL2 Antikörper (ABIN2856034)

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LOXL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Güteklasse: KO Validated

Produktdetails anti-LOXL2 Antikörper

Spezifität: Mouse reactivity has been validated by IHC-P only, not yet been tested by other applications.

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to LOXL2 (lysyl oxidase-like 2)
LOXL2 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human LOXL2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: U87-MG , SK-N-SH , SK-N-AS , 293T transfected with LOXL2

Validation: KO/KD, Orthogonal, Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.86 mg/mL

Buffer: 1XPBS, 20 % Glycerol ( pH 7), 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-LOXL2 Antikörper (ABIN2856034)

Cao, Lin, Zhi, Lazare, Meng, Wu, Gao, Wei, Wu: "LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype." in: Frontiers in oncology, Vol. 10, pp. 284, (2020) (PubMed).

Mahjour, Dambal, Shrestha, Singh, Noonan, Kantarci, Trackman: "Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB." in: Oncogenesis, Vol. 8, Issue 5, pp. 34, (2019) (PubMed).

Wang, Zhao, Zhu, Liu, Liang, Liu, Zhang, Dong, Sun: "HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 60, (2018) (PubMed).

Aumiller, Strobel, Romeike, Schuler, Stierstorfer, Kreuz: "Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis." in: Scientific reports, Vol. 7, Issue 1, pp. 149, (2018) (PubMed).

Bais, Kukuruzinska, Trackman: "Orthotopic non-metastatic and metastatic oral cancer mouse models." in: Oral oncology, Vol. 51, Issue 5, pp. 476-82, (2015) (PubMed).

Details zu LOXL2

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Andere Bezeichnung: lysyl oxidase like 2

Hintergrund: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Cellular Localization: Secreted , extracellular space

Molekulargewicht: 87 kDa

Gen-ID: 4017

UniProt: Q9Y4K0

Pathways: Chromatin Binding