MSH3 Antikörper (N-Term)

Produktnummer ABIN2855583

Dieses Anti-MSH3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MSH3 in WB. Geeignet für Human.

Kurzübersicht für MSH3 Antikörper (N-Term) (ABIN2855583)

Target: MSH3 (MutS Homolog 3 (MSH3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MSH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MSH3 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Rind (Kuh)

Kreuzreaktivität (Details): Bovine (83 %)

Produktmerkmale: Rabbit Polyclonal antibody to MSH3 (mutS homolog 3 (E. coli))
MSH3 antibody [N1N2], N-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human MSH3. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Kommentare:

Positive Control: A549 , H1299 , HCT116

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Andere Bezeichnung: MSH3

Hintergrund: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Molekulargewicht: 127 kDa

Gen-ID: 4437

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response