GFR Antikörper (N-Term)

Produktnummer ABIN2855444

Der Kaninchen-Polyklonal Anti-GFR-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von GFR in Proben aus Human. }

Kurzübersicht für GFR Antikörper (N-Term) (ABIN2855444)

Target: GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GFR Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human

Produktmerkmale: Rabbit polyclonal antibody to RAPGEF5 (Rap guanine nucleotide exchange factor (GEF) 5)
RAPGEF5 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human RAPGEF5. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLaS3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.74 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu GFR

Target: GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))

Andere Bezeichnung: Rap guanine nucleotide exchange factor 5

Hintergrund: Members of the RAS (see HRAS, MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]

Cellular Localization: Nucleus

Molekulargewicht: 68 kDa

Gen-ID: 9771

UniProt: Q92565

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, Hepatitis C