NOTCH3 Antikörper (C-Term)

Produktnummer ABIN2854480

Produktdetails anti-NOTCH3 Antikörper

Target: NOTCH3 (Notch 3 (NOTCH3))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): Mouse (100 %), Rat (100 %)

Produktmerkmale: Rabbit polyclonal antibody to Notch 3 (Notch homolog 3 (Drosophila))
Notch 3 antibody [C3], C-term

Aufreinigung: Affinity purified by Protein A.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Notch 3. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Kommentare:

Positive Control: HeLa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.26 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: Notch 3 (NOTCH3 Produkte)

Synonyme: CADASIL antikoerper, CASIL antikoerper, IMF2 antikoerper, AW229011 antikoerper, N3 antikoerper, hpbk antikoerper, fa14b08 antikoerper, notch5 antikoerper, wu:fa14b08 antikoerper, notch 3 antikoerper, NOTCH3 antikoerper, Notch3 antikoerper, notch3 antikoerper

Hintergrund: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Cellular Localization: Cell membrane, Single-pass type I membrane protein , Notch 3 intracellular domain: Nucleus

Molekulargewicht: 244 kDa

Gen-ID: 4854

Pathways: Notch Signalweg