Perforin 1 Antikörper (N-Term)
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- Target Alle Perforin 1 (PRF1) Antikörper anzeigen
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Perforin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Human
- Produktmerkmale
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Rabbit polyclonal antibody to Perforin 1 (perforin 1 (pore forming protein))
Perforin 1 antibody [N1N3] - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the N-terminus region of human Perforin 1. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product PRF1 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: HepG2
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.37 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- Andere Bezeichnung
- perforin 1 (PRF1 Produkte)
- Synonyme
- FLH2 antikoerper, HPLH2 antikoerper, P1 antikoerper, PFN1 antikoerper, PFP antikoerper, PRF1 antikoerper, Pfn antikoerper, Pfp antikoerper, Prf-1 antikoerper, Cyta antikoerper, RATCYTA antikoerper, LOC443187 antikoerper, perforin antikoerper, prf1 antikoerper, cytolysin antikoerper, perforin-1 antikoerper, perforin-1-like antikoerper, perforin 1 antikoerper, perforin 1 (pore forming protein) antikoerper, perforin antikoerper, perforin 1 L homeolog antikoerper, PRF1 antikoerper, Prf1 antikoerper, LOC443187 antikoerper, prf1 antikoerper, prf1.L antikoerper
- Hintergrund
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The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Cellular Localization: Cytoplasmic granule membrane, Multi-pass membrane protein - Molekulargewicht
- 61 kDa
- Gen-ID
- 5551
- UniProt
- P14222
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose
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