SOCS1 Antikörper (AA 2-78) (Biotin)

Produktnummer ABIN2853615

Produktdetails anti-SOCS1 Antikörper (Biotin)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Bindungsspezifität: AA 2-78

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOCS1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts with mouse SOCS-1. Customer reports that the antibody worked successfully in the human myoblastic cell line, KG-1 by Western blotting.

Aufreinigung: Protein A agarose

Klon: 4H1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3.

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1 (SOCS1 Produkte)

Hintergrund: The Suppressor of Cytokine Signaling (SOCS) family of proteins act in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24 kDa protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also induced by and inhibits the signaling action of IL-3, IL-4, LIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN- γ signaling and T cell differentiation.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3

Molekulargewicht: 28 kDa

Gen-ID: 8651

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus