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14-3-3 sigma/SFN Antikörper (AA 101-200) (AbBy Fluor® 594)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch 14-3-3 sigma/SFN in WB, IF (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Human und Ratte.
Produktnummer ABIN2809284

Kurzübersicht für 14-3-3 sigma/SFN Antikörper (AA 101-200) (AbBy Fluor® 594) (ABIN2809284)

Target

Alle 14-3-3 sigma/SFN (SFN) Antikörper anzeigen
14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Reaktivität

  • 115
  • 42
  • 34
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte

Wirt

  • 95
  • 20
  • 2
  • 1
Kaninchen

Klonalität

  • 89
  • 29
Polyklonal

Konjugat

  • 55
  • 11
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser 14-3-3 sigma/SFN Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation

  • 93
  • 53
  • 36
  • 24
  • 21
  • 16
  • 13
  • 12
  • 12
  • 11
  • 11
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
  • Bindungsspezifität

    • 17
    • 14
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-200

    Kreuzreaktivität

    Human, Ratte

    Homologie

    Mouse,Dog,Sheep,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human 14-3-3 sigma

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

    Andere Bezeichnung

    14-3-3 sigma

    Hintergrund

    Synonyms: 14 3 3 protein sigma, 14-3-3 protein sigma, 1433S_HUMAN, Epithelial cell marker protein 1, Er, HME 1, HME1, MGC143283, Mkrn3, Mme1, OTTHUMP00000004242, RP23 137L22.11, SFN, SFN protein, Stratin, YWHAS.

    Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.

    Gen-ID

    2810

    Pathways

    p53 Signalweg, Myometrial Relaxation and Contraction
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