RAD17 Antikörper (pSer645) (AbBy Fluor® 594)

Produktnummer ABIN2805760

Der Kaninchen Polyklonal Anti-RAD17-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, RAD17 in Proben von Human zu detektieren.

Kurzübersicht für RAD17 Antikörper (pSer645) (AbBy Fluor® 594) (ABIN2805760)

Target: RAD17

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD17 Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-RAD17 Antikörper (AbBy Fluor® 594)

Bindungsspezifität: pSer645

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RAD17

Target: RAD17

Andere Bezeichnung: Rad17

Hintergrund:

Synonyms: CCYC, Cell cycle checkpoint protein, Cell cycle checkpoint protein RAD17, HRAD 17, HRAD17, R24L, Rad 17, Rad 24, RAD1 S. pombe homolog, RAD17 homolog, Rad17 like protein, RAD17Sp, Rad24, RF C activator 1 homolog, RF C/activator 1 homolog.

Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].

Gen-ID: 5884