MSH3 Antikörper (AA 651-750) (AbBy Fluor® 594)

Produktnummer ABIN2804316

Der Kaninchen Polyklonal Anti-MSH3-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, MSH3 in Proben von Human zu detektieren.

Kurzübersicht für MSH3 Antikörper (AA 651-750) (AbBy Fluor® 594) (ABIN2804316)

Target: MSH3 (MutS Homolog 3 (MSH3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MSH3 Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-MSH3 Antikörper (AbBy Fluor® 594)

Bindungsspezifität: AA 651-750

Homologie: Human,Mouse,Rat,Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MSH3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Andere Bezeichnung: MSH3

Hintergrund:

Synonyms: Divergent upstream protein, DNA mismatch repair protein, DNA mismatch repair protein Msh 3, DNA mismatch repair protein Msh3, DUC 1, DUC1, DUG, DUP, hMSH3, Mismatch repair protein 1, MRP 1, MRP1, MSH 3, MSH-3, MSH3_HUMAN, MutS homolog 3.

Background: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Gen-ID: 4437

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response