Caveolin-1 Antikörper (N-Term)

Produktnummer ABIN2792696

Produktdetails anti-Caveolin-1 Antikörper

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Hund, Schwein, Kaninchen, Rind (Kuh), Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caveolin-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SGGKYVDSEG HLYTVPIREQ GNIYKPNNKA MADELSEKQV YDAHTKEIDL

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Homologie: Cow: 80%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%, Sheep: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against CAV1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAV1

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-CAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human Liver.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 178 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Andere Bezeichnung: Caveolin-1 (CAV1 Produkte)

Synonyme: fc07c04 antikoerper, wu:fc07c04 antikoerper, Cav-1 antikoerper, bscl3 antikoerper, cav1 antikoerper, cav1a antikoerper, cgl3 antikoerper, vip21 antikoerper, cav1b antikoerper, caveolin-1 antikoerper, cav antikoerper, mstp085 antikoerper, Caveolin-1 antikoerper, CAV1 antikoerper, cav-1 antikoerper, Cav antikoerper, caveolin 1 antikoerper, BSCL3 antikoerper, CGL3 antikoerper, MSTP085 antikoerper, PPH3 antikoerper, VIP21 antikoerper, caveolin 1 antikoerper, caveolin 1 L homeolog antikoerper, caveolin 1 S homeolog antikoerper, caveolin 1, caveolae protein antikoerper, caveolin 1, caveolae protein, 22kDa antikoerper, Caveolin antikoerper, cav1 antikoerper, cav1.L antikoerper, cav1.S antikoerper, CAV1 antikoerper, Cav1 antikoerper, cav-1 antikoerper

Hintergrund: The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAV, MSTP085, VIP21, CGL3, BSCL3
Protein Interaction Partner: TFRC, ABCC1, UBC, RPA3, ATG5, ATG12, RPA2, RPA1, PTGIS, EGFR, VCP, UFD1L, PTGS2, PTGS1, ESR1, DERL1, VIMP, ATP4A, CAV2, GLIPR2, KDR, PROCR, F2R, BID, NOS3, HSP90AA1, FAS, ACTB, MALL, NF1, LRP6, KCNMA1, BMPR2, BMPR1A, AXIN1, PPP2CA, MCL1, ITPR3, ID1, TENC1
Protein Size: 178

Molekulargewicht: 20 kDa

Gen-ID: 857

NCBI Accession: NM_001753, NP_001744

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals