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CTNNB1 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CTNNB1 in WB und ChIP. Er zeigt eine Reaktivität gegenüber Human, Maus, Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen und Meerschweinchen und wurde in 1 Publikation erwähnt.
Produktnummer ABIN2792527

Kurzübersicht für CTNNB1 Antikörper (C-Term) (ABIN2792527)

Target

Alle CTNNB1 Antikörper anzeigen
CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Reaktivität

  • 229
  • 121
  • 107
  • 33
  • 24
  • 22
  • 20
  • 17
  • 12
  • 10
  • 10
  • 9
  • 7
  • 7
  • 5
  • 5
  • 1
Human, Maus, Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen, Meerschweinchen

Wirt

  • 151
  • 76
  • 3
  • 2
Kaninchen

Klonalität

  • 140
  • 92
Polyklonal

Konjugat

  • 197
  • 8
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CTNNB1 Antikörper ist unkonjugiert

Applikation

  • 199
  • 98
  • 93
  • 81
  • 43
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  • 38
  • 30
  • 12
  • 6
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
  • Bindungsspezifität

    • 24
    • 16
    • 13
    • 12
    • 10
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
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    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequenz

    RTEPMAWNET ADLGLDIGAQ GEPLGYRQDD PSYRSFHSGG YGQDALGMDP

    Kreuzreaktivität

    Rind (Kuh), Hund, Huhn, Human, Maus, Schwein, Ratte (Rattus)

    Homologie

    Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Zebrafish: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against CTNNB1. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C-terminal region of human CTNNB1
  • Applikationshinweise

    WB Suggested Anti-CTNNB1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:62500
    Positive Control: Human heart.
    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 781 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Li, Yang, Tang, Zhang, Feng, Cui: "Repair of massively defected hemi-joints using demineralized osteoarticular allografts with protected cartilage." in: Journal of materials science. Materials in medicine, Vol. 26, Issue 8, pp. 227, (2015) (PubMed).

  • Target

    CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

    Andere Bezeichnung

    CTNNB1 / Beta Catenin

    Hintergrund

    Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-54 DA216720.1 1-54 55-2626 X87838.1 1-2572 2627-3720 AC104307.2 83770-84863
    Alias Symbols: CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
    Protein Interaction Partner: PPARD, PLA2G4A, FBXO45, BTRC, SUMO1, UBC, HUWE1, CDH5, CDH2, TCF4, TBL1X, SOX1, SKP1, RNF220, CACYBP, FBXW11, SUMO2, SIAH1, Apc2, COPS5, RNF14, CDH1, SP1, KCTD1, MDM2, UBE2B, GSK3B, NEK2, RBX1, PTGS2, STRN3, LATS2, APC, ELAVL1, AMOT, ABL1, AXIN1, CBL, LEF
    Protein Size: 781

    Molekulargewicht

    85 kDa

    Gen-ID

    1499

    NCBI Accession

    NM_001904, NP_001895

    UniProt

    P35222

    Pathways

    WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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