Cyclin H Antikörper (C-Term)

Produktnummer ABIN2792161

Der Kaninchen Polyklonal anti-Cyclin H Antikörper (ABIN2792161) detektiert spezifisch Cyclin H in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Meerschweinchen, Kaninchen und Pferd.

Kurzübersicht für Cyclin H Antikörper (C-Term) (ABIN2792161)

Target: Cyclin H (CCNH)

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Cyclin H Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CCNH Antibody - C-terminal region

Sequenz: KQKLERCHSA ELALNVITKK RKGYEDDDYV SKKSKHEEEE WTDDDLVESL

Homologie: Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 83%, Rabbit: 83%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against CCNH. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CCNH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Cyclin H

Target: Cyclin H (CCNH)

Andere Bezeichnung: CCNH

Hintergrund:

Background Information: Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Gene Name: Cyclin H

Alternative Symbols: CAK, p34, p37, CycH

Protein Name: Cyclin-H

Molekulargewicht: 38 kDa

Gen-ID: 902

NCBI Accession: NP_001230

UniProt: P51946

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase