FANCD2 Antikörper (Middle Region)

Produktnummer ABIN2792058

Produktdetails anti-FANCD2 Antikörper

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TPHTVTAISA KIRKKGKIER KQKTDGSKTS SSDTLSEEKN SECDPTPSHR

Homologie: Horse: 79%, Human: 100%, Pig: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against FANCD2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FANCD2

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Andere Bezeichnung: FANCD2 (FANCD2 Produkte)

Synonyme: FANCD2 antikoerper, CG17269 antikoerper, CG31192 antikoerper, CG31194 antikoerper, Dmel\\CG17269 antikoerper, dmFANCD2 antikoerper, xfancd2 antikoerper, FA-D2 antikoerper, FA4 antikoerper, FACD antikoerper, FAD antikoerper, FAD2 antikoerper, FANCD antikoerper, 2410150O07Rik antikoerper, AU015151 antikoerper, BB137857 antikoerper, Fanconi anemia complementation group D2 antikoerper, CG17269 gene product from transcript CG17269-RA antikoerper, Fanconi anemia group D2 protein antikoerper, Fanconi anemia, complementation group D2 antikoerper, Fanconi anemia complementation group D2 L homeolog antikoerper, FANCD2 antikoerper, Fancd2 antikoerper, LOC100455970 antikoerper, fancd2 antikoerper, fancd2.L antikoerper

Hintergrund: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.
Alias Symbols: FA4, FAD, FACD, FAD2, FA-D2, FANCD
Protein Size: 749

Molekulargewicht: 82 kDa

Gen-ID: 2177

NCBI Accession: NM_001018115, NP_001018125

UniProt: Q9BXW9

Pathways: DNA Reparatur