FANCD2 Antikörper (AA 893-927)

Produktnummer ABIN6243659

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FANCD2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FANCD2 Antikörper (AA 893-927) (ABIN6243659)

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB49367

Produktdetails anti-FANCD2 Antikörper

Bindungsspezifität: AA 893-927

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FANCD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 893-927 amino acids from the Central region of human FANCD2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Andere Bezeichnung: FANCD2

Hintergrund: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

Molekulargewicht: 164128

UniProt: Q9BXW9

Pathways: DNA Reparatur