MMP25 Antikörper (Middle Region)

Produktnummer ABIN2789901

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MMP25 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für MMP25 Antikörper (Middle Region) (ABIN2789901)

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MMP25 Antikörper

Bindungsspezifität: Middle Region

Sequenz: FGHALGLGHS SAPNSIMRPF YQGPVGDPDK YRLSQDDRDG LQQLYGKAPQ

Homologie: Dog: 82%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against MMP25. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 562 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MMP25

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Andere Bezeichnung: MMP25

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Alias Symbols: MMP20, MMP20A, MMPL1, MT-MMP6, MT6-MMP
Protein Interaction Partner: CLU, MMP2,
Protein Size: 562

Molekulargewicht: 48 kDa

Gen-ID: 64386

NCBI Accession: NM_022468, NP_071913

UniProt: Q9NPA2