DUSP4 Antikörper (C-Term)

Produktnummer ABIN2789728

Produktdetails anti-DUSP4 Antikörper

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GQLLQFESQV LATSCAAEAA SPSGPLRERG KTPATPTSQF VFSFPVSVGV

Homologie: Cow: 92%, Dog: 85%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 85%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against DUSP4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 394 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DUSP4

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Andere Bezeichnung: DUSP4 (DUSP4 Produkte)

Hintergrund: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Alias Symbols: HVH2, MKP-2, MKP2, TYP
Protein Interaction Partner: UBC, MAPK8, MAPK3, APP, CRMP1, GRIN1, MAPK9, GRIN2D, MAPK14, MAPK1,
Protein Size: 394

Molekulargewicht: 43 kDa

Gen-ID: 1846

NCBI Accession: NM_001394, NP_001385

UniProt: Q13115

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades