ABI1 Antikörper (C-Term)

Produktnummer ABIN2789495

Der Kaninchen Polyklonal Anti-ABI1-Antikörper wurde für WB validiert. Er ist geeignet, ABI1 in Proben von Human, Ratte, Maus, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Hund und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für ABI1 Antikörper (C-Term) (ABIN2789495)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reaktivität: Human, Ratte, Maus, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ABI1 Antikörper

Bindungsspezifität: C-Term

Sequenz: IEKVVAIYDY TKDKDDELSF MEGAIIYVIK KNDDGWYEGV CNRVTGLFPG

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ABI1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 388 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Andere Bezeichnung: ABI1

Hintergrund: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Alias Symbols: ABI-1, E3B1, NAP1BP, SSH3BP, SSH3BP1, ABLBP4
Protein Interaction Partner: ABL1, UBC, PRPF40A, TCERG1, GAS7, APBB1, SRRM1, PRKAA1, PIK3R1, CDC123, CTTN, NCK2, NCK1, CBL, CACNA1A, RYK, EPS8L1, ENAH, MINK1, EVL, NIN, CYFIP2, HSPA8, WASF2, WASF1, PAK2, NCKAP1, ABI1, VASP, SOS2, EPS8, NCF1, SPTA1, SPTAN1, SOS1, NEB, EPS8L3, EPS8L2,
Protein Size: 388

Molekulargewicht: 42 kDa

Gen-ID: 10006

NCBI Accession: NM_001178124, NP_001171595

UniProt: B6VEX5

Pathways: RTK Signalweg, Response to Water Deprivation, ER-Nucleus Signaling