TPMT Antikörper (C-Term)

Produktnummer ABIN2789428

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TPMT in WB. Er zeigt eine Reaktivität gegenüber Human, Hund und Schwein.

Kurzübersicht für TPMT Antikörper (C-Term) (ABIN2789428)

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reaktivität: Human, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TPMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TPMT Antikörper

Bindungsspezifität: C-Term

Sequenz: RGALVAINPG DRKCYADTMF SLLGKKFQYL LCVLSYDPTK HPGPPFYVPH

Homologie: Dog: 79%, Human: 100%, Pig: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TPMT. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 245 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Andere Bezeichnung: TPMT

Hintergrund: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Alias Symbols: -
Protein Interaction Partner: APP, UBC,
Protein Size: 245

Molekulargewicht: 27 kDa

Gen-ID: 7172

NCBI Accession: NM_000367, NP_000358

UniProt: P51580