HLAG Antikörper (C-Term)

Produktnummer ABIN2789375

Der Kaninchen Polyklonal anti-HLAG Antikörper (ABIN2789375) detektiert spezifisch HLAG in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Rind (Kuh) und Schwein.

Kurzübersicht für HLAG Antikörper (C-Term) (ABIN2789375)

Target: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Reaktivität: Human, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLAG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HLAG Antikörper

Bindungsspezifität: C-Term

Sequenz: HPVFDYEATL RCWALGFYPA EIILTWQRDG EDQTQDVELV ETRPAGDGTF

Homologie: Cow: 93%, Human: 100%, Pig: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-G. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 338 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HLAG

Target: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Andere Bezeichnung: HLA-G

Hintergrund: HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
Alias Symbols: MHC-G
Protein Interaction Partner: UBC, FAF2, KIR2DL4, LILRB2, LILRB1, KLRD1, COPB1, CD8A, TAP2, TAP1, HLA-G, B2M,
Protein Size: 338

Molekulargewicht: 36 kDa

Gen-ID: 3135

NCBI Accession: NM_002127, NP_002118

UniProt: P17693

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response