HLA-C Antikörper (C-Term)

Produktnummer ABIN2789353

Der Kaninchen Polyklonal anti-HLA-C Antikörper (ABIN2789353) detektiert spezifisch HLA-C in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Schwein und Kaninchen.

Kurzübersicht für HLA-C Antikörper (C-Term) (ABIN2789353)

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Reaktivität: Human, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HLA-C Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: HLA-C Antibody - C-terminal region

Sequenz: PPKTHVTHHP LSDHEATLRC WALGFYPAEI TLTWQRDGED QTQDTELVET

Homologie: Human: 100%, Pig: 100%, Rabbit: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-C. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63059-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-C

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Andere Bezeichnung: HLA-C

Hintergrund:

Background Information: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.

Gene Name: Major histocompatibility complex, class I, C

Alternative Symbols: MHC, HLAC, HLC-C, D6S204, PSORS1, HLA-JY3

Protein Name: HLA class I histocompatibility antigen, Cw-16 alpha chain

Molekulargewicht: 38kDa

Gen-ID: 3107

NCBI Accession: NP_002108

UniProt: Q29960

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response