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HLA-C Antikörper (AA 66-93)

HLA-C Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB21680 unconjugated
Produktnummer ABIN1538555
  • Target Alle HLA-C Antikörper anzeigen
    HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 66-93
    Reaktivität
    • 59
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 50
    • 9
    Kaninchen
    Klonalität
    • 51
    • 8
    Polyklonal
    Konjugat
    • 24
    • 9
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-C Antikörper ist unkonjugiert
    Applikation
    • 34
    • 30
    • 11
    • 8
    • 7
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
    Klon
    RB21680
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    HLA-C Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
    Andere Bezeichnung
    HLA-C (HLA-C Produkte)
    Synonyme
    D6S204 antikoerper, HLA-JY3 antikoerper, HLC-C antikoerper, PSORS1 antikoerper, major histocompatibility complex, class I, C antikoerper, HLA-C antikoerper
    Hintergrund
    HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
    Molekulargewicht
    40649
    Gen-ID
    3107
    NCBI Accession
    NP_002108
    UniProt
    P10321
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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