BRE Antikörper (C-Term)

Produktnummer ABIN2789082

Produktdetails anti-BRE Antikörper

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BRE. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 383 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BRE

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Andere Bezeichnung: BRE (BRE Produkte)

Synonyme: brcc4 antikoerper, brcc45 antikoerper, BRE antikoerper, LOC100231620 antikoerper, BRCC4 antikoerper, BRCC45 antikoerper, 6030405P19Rik antikoerper, AI429776 antikoerper, B830038C02Rik antikoerper, im:7141046 antikoerper, zgc:110368 antikoerper, BRISC and BRCA1 A complex member 2 antikoerper, brain and reproductive organ-expressed (TNFRSF1A modulator) antikoerper, BRISC and BRCA1 A complex member 2 L homeolog antikoerper, babam2 antikoerper, BABAM2 antikoerper, Babam2 antikoerper, BRE antikoerper, babam2.L antikoerper

Hintergrund: BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: FAM175B, UBC, BABAM1, AKAP2, TFG, OPTN, HNRNPA2B1, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, UBD, GFI1B, UIMC1, BRCC3, FAM175A, NCOA3, COPS5, SUMO1, TNFRSF1A, FAS, MMS19, UGGT2, TMX3, DHRS7B, FKBP8, TTC28, ATG2A, SLC25A13, LRPPRC, USP7, SSR3, SHMT2, RPN2, PHB, UB
Protein Size: 383

Molekulargewicht: 43 kDa

Gen-ID: 9577

NCBI Accession: NM_199194, NP_954664

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus