GCK Antikörper (N-Term)

Produktnummer ABIN2788816

Dieses Anti-GCK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GCK in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Schaf, Kaninchen, Meerschweinchen, Hund und Pferd. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GCK Antikörper (N-Term) (ABIN2788816)

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schaf, Kaninchen, Meerschweinchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GCK Antikörper

Bindungsspezifität: N-Term

Sequenz: RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against GCK. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 464 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GCK Antikörper (ABIN2788816)

Tian, Liu, Wang, Dong, Su, Ma, Zhang: "Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." in: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).

Details zu GCK

Target: GCK (Glucokinase (Hexokinase 4) (GCK))

Andere Bezeichnung: GCK

Hintergrund: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Alias Symbols: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK
Protein Interaction Partner: PCNA, GCKR, INS, PFKFB2, MIG1,
Protein Size: 464

Molekulargewicht: 51 kDa

Gen-ID: 2645

NCBI Accession: NM_033508, NP_277043

Pathways: MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process