CMA1 Antikörper (C-Term)

Produktnummer ABIN2788295

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CMA1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen und Schaf.

Kurzübersicht für CMA1 Antikörper (C-Term) (ABIN2788295)

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CMA1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CMA1 Antibody - C-terminal region

Sequenz: EVKLRLMDPQ ACSHFRDFDH NLQLCVGNPR KTKSAFKGDS GGPLLCAGVA

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CMA1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CMA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59991-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CMA1

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Andere Bezeichnung: CMA1

Hintergrund:

Background Information: CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.

Gene Name: Chymase 1, mast cell

Alternative Symbols: CYH, MCT1, chymase

Protein Name: Chymase

Molekulargewicht: 27kDa

Gen-ID: 1215

NCBI Accession: NP_001827

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis