alpha Adaptin Antikörper (C-Term)

Produktnummer ABIN2788287

Produktdetails anti-alpha Adaptin Antikörper

Target: alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha Adaptin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ILAKLKRKKG PGAGSALDDG RRDPSSNDIN GGMEPTPSTV STPSPSADLL

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against AP2A1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AP2A1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 955 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu alpha Adaptin

Target: alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))

Andere Bezeichnung: AP2A1 (AP2A1 Produkte)

Synonyme: ADTAA antikoerper, AP2-ALPHA antikoerper, CLAPA1 antikoerper, adtaa antikoerper, clapa1 antikoerper, ap2-alpha antikoerper, AP2A1 antikoerper, Adtaa antikoerper, adaptor related protein complex 2 alpha 1 subunit antikoerper, adaptor-related protein complex 2, alpha 1 subunit antikoerper, AP-2 complex subunit alpha-1 antikoerper, AP2A1 antikoerper, ap2a1 antikoerper, Ap2a1 antikoerper, EDI_093420 antikoerper, EDI_259990 antikoerper

Hintergrund: This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
Alias Symbols: ADTAA, AP2-ALPHA, CLAPA1
Protein Interaction Partner: SUMO2, SUMO3, UBC, EGFR, EPHA2, ABCB11, RPA3, RPA2, RPA1, BIN1, PIN1, GRB2, PPP6R3, RNF11, ARRB1, MMS19, SMAD9, ITGA4, FN1, DAB2, VCAM1, PICALM, AP2A2, SHC1, MYO6, GRK5, EPS15, CRK, AP2M1, ABL1, AMPH, Epn1, RALBP1, REPS2, SYNJ1, SHBG, BRCA1, ARRB2, Edc4,
Protein Size: 955

Molekulargewicht: 105 kDa

Gen-ID: 160

NCBI Accession: NM_130787, NP_570603

UniProt: O95782

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation