alpha Adaptin Antikörper (AA 1-260)

Produktnummer ABIN7144361

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch alpha Adaptin in IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für alpha Adaptin Antikörper (AA 1-260) (ABIN7144361)

Target: alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha Adaptin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-alpha Adaptin Antikörper

Bindungsspezifität: AA 1-260

Verwendungszweck: AP2A1 Antibody

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human AP-2 complex subunit alpha-1 protein (1-260AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu alpha Adaptin

Target: alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))

Andere Bezeichnung: AP2A1

Hintergrund:

Background: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).

Aliases: 100 kDa coated vesicle protein A antibody, Adapter-related protein complex 2 alpha-1 subunit antibody, adapter-related protein complex 2 subunit alpha-1 antibody, Adaptin alpha A antibody, Adaptin alpha antibody, Adaptor protein complex AP 2 alpha 1 subunit antibody, adaptor protein complex AP 2 subunit alpha 1 antibody, Adaptor protein complex AP-2 subunit alpha-1 antibody, Adaptor protein complex AP2 alpha 1 subunit antibody, adaptor protein complex AP2 subunit alpha 1 antibody, Adaptor related protein complex 2 alpha 1 subunit antibody, Adaptor related protein complex AP 2 alpha 1 subunit antibody, Adaptor related protein complex AP2 alpha 1 subunit antibody, ADTAA antibody, Alpha A adaptin antibody, Alpha adaptin A antibody, Alpha-adaptin A antibody, alpha1 adaptin antibody, Alpha1-adaptin antibody, AP 2 alpha antibody, AP 2 complex subunit alpha 1 antibody, AP-2 complex subunit alpha-1 antibody, AP2 complex subunit alpha 1 antibody, AP2-ALPHA antibody, Ap2a1 antibody, AP2A1_HUMAN antibody, CLAPA 1 antibody, CLAPA1 antibody, Clathrin adaptor complex AP2. alpha subunit antibody, Clathrin assembly protein complex 2 alpha A large chain antibody, Clathrin assembly protein complex 2 alpha-A large chain antibody, Clathrin associated / assembly / adaptor protein large alpha 1 antibody, clathrin associated assembly adaptor protein large alpha 1 antibody, clathrin associated/assembly/adaptor protein, large, alpha 1 antibody, Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody

UniProt: O95782

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation